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Synonym: (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride, (2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride, (2S,3S)-Hydroxybupropion hydrochloride, GW 353162, Radafaxine hydrochloride, SS-hydroxybupropion hydrochloride
Empirical Formula (Hill Notation): C13H18ClNO2 · HCl
Molecular Weight: 292.20
CAS Number: 106083-71-0
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|solubility||DMSO: 12 mg/mL|
(2S,3S)-hydroxybupropion is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. (2S,3S)-hydroxybupropion is a major metabolite of bupropion. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in -dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of reward in mice.
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