|Home||» Products||» Biochemical & Reagents||» (S)-(+)-Camptothecin|
Empirical Formula (Hill Notation): C20H16N2O4
Molecular Weight: 348.35
CAS Number: 7689-03-4
|mp||260 °C (dec.)(lit.)|
|solubility||chloroform/methanol (4:1): soluble5 mg/mL|
|Mode of action||DNA synthesis | interferes|
|enzyme | inhibits|
|Gene Information|| human ... TOP1(7150)|
mouse ... Prkca(18750)
rat ... Sstr2(54305)
1 g in glass bottle
100, 250 mg in glass bottle
(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
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