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(S)-(+)-Camptothecin

(S)-(+)-Camptothecin
(S)-(+)-Camptothecin
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Product Code : 604
Price And Quantity
  • Minimum Order Quantity
  • 1 Kilograms
  • Price
  • 100 Onwards INR
Product Specifications
  • Usage
  • As a result of these efforts, two camptothecin analogs have been approved for cancer therapy: Topotecan (hycamtin) is approved for the treatment of recurring ovarian cancer, small cell lung cancer, and in combination with cisplatin for cervical cancer; irinotecan (camptosar) is prescribed for advanced cancers of the ...
  • Boiling point
  • 757.0�60.0 �C at 760 mmHg
  • Molecular Weight
  • 348.352 Grams (g)
  • Melting Point
  • 275 to 277 �C (527 to 531 �F)
  • Molecular Formula
  • C20H16N2O4
  • Chemical Name
  • Camptothecin
Product Description

(S)-(+)-Camptothecin


    • Empirical Formula (Hill Notation): C20H16N2O4

    • Molecular Weight: 348.35

    • CAS Number: 7689-03-4

      assay  


      ≥90% (HPLC)
      form   powder
      mp   260 Â°C (dec.)(lit.)
      solubility   chloroform/methanol (4:1): soluble5 mg/mL
      Mode of action   DNA synthesis | interferes
        enzyme | inhibits
      storage temp.   2-8°C
      Gene Information   human ... TOP1(7150)
      mouse ... Prkca(18750)
      rat ... Sstr2(54305)

      Description

      Other Notes

      20S isomer

      Packaging

      1 g in glass bottle

      100, 250 mg in glass bottle

      Biochem/physiol Actions

      (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.

      Features and Benefits

      This compound is a featured product for Apoptosis research.

       

Trade Information
  • Payment Terms
  • Cash in Advance (CID), Cash Advance (CA)
  • Supply Ability
  • 500 Kilograms KG Per Month
  • Delivery Time
  • 2-8 Week
  • Sample Available
  • Yes
  • Sample Policy
  • Sample costs shipping and taxes has to be paid by the buyer
  • Packaging Details
  • Carton and Poly Bag.
  • Main Export Market(s)
  • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
  • Main Domestic Market
  • All India

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