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(S)-(−)-Propranolol hydrochloride

(S)-(−)-Propranolol hydrochloride
(S)-(−)-Propranolol hydrochloride
Product Code : 608
Product Description

(S)-()-Propranolol hydrochloride

  • Synonym: (S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride

    • Linear Formula: C10H7OCH2CH(OH)CH2NHCH(CH3)2·HCl

    • Molecular Weight: 295.80

    • CAS Number: 4199-10-4

      assay  


      98% (TLC)
      form   powder
      optical activity   [α]25/D 25.5°, c = 1.0 in ethanol(lit.)
      mp   193-195 °C(lit.)
      solubility   ethanol: soluble10 mg/mL
        DMSO: <14.5 mg/mL
        H2O: soluble50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
        45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble8.0 mg/mL
      originator   AstraZeneca
      storage temp.   2-8°C
      Gene Information   human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)
      Show Fewer Properties

       

      Description

      Packaging

      100, 500 mg in glass bottle

      Biochem/physiol Actions

      Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites

      Features and Benefits

      This compound is featured on the β-Adrenoceptors

       

 


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