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(±)-Sulpiride

(±)-Sulpiride
(±)-Sulpiride
Product Code : 534
Product Description

(±)-Sulpiride

  • Synonym: (±)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, (±)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide

    • Empirical Formula (Hill Notation): C15H23N3O4S

    • Molecular Weight: 341.43

    • CAS Number: 15676-16-1

form  

powder
color   white
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble8.0 mg/mL
  0.1 M HCl: soluble
  H2O: slightly soluble
  ethanol: soluble
originator   Sanofi Aventis
storage temp.   2-8°C
Gene Information   human ... CA1(759), CA2(760), CA4(762), CA5A(763), CA5B(11238), CA9(768), DRD2(1813)
Show Fewer Properties

Description

Reconstitution

Solutions may be stored for several days at 4 °C.

Application

(±)-Sulpiride was used to study the effect of dopamine D2 receptor signaling on calcium channels in rat pituitary melanotropic cells.47

Biochem/physiol Actions

(±)-Sulpiride is a D2 dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D2-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.45,46

Features and Benefits

This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC), a biologically annotated collection of high-quality, ready-to-screen compounds. 

This compound was developed by Sanofi Aventis.


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