Cookie Img
Home » Products » Biochemical & Reagents » (+)-Thalidomide

(+)-Thalidomide

(+)-Thalidomide
(+)-Thalidomide
Product Code : 556
Product Description

(+)-Thalidomide

  • Synonym: R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

    • Empirical Formula (Hill Notation): C13H10N2O4

    • Molecular Weight: 258.23

    • CAS Number: 2614-06-4

 

assay  


98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: soluble15 mg/mL, clear
originator   Celgene
storage temp.   room temp
Gene Information   human ... LITAF(9516), TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)

Description

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

Preparation Note

Thalidomide is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml. It is insoluble in ethanol and water.

Application

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis[1]. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos[2].

Features and Benefits

This compound was developed by Celgene.

 


NATIONAL ANALYTICAL CORPORATION

Contact Us

( *represents compulsory fields )

Tips on getting accurate quotes. Please include product name, order quantity, usage, special requests if any in your inquiry.



NATIONAL ANALYTICAL CORPORATION All Rights Reserved.