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(+)-Thalidomide

(+)-Thalidomide
(+)-Thalidomide
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Product Code : 556
Price And Quantity
  • Minimum Order Quantity
  • 1 Kilograms
  • Price
  • 100 Onwards INR
Product Specifications
  • Density
  • 1.6�0.1 g/cm3
  • Appearance
  • White Solid
  • Molecular Weight
  • 258.23
  • Melting Point
  • 273-276�C
  • Molecular Formula
  • C13H10N2O4
  • Chemical Name
  • (+)-Thalidomide
  • Purity(%)
  • 99%
Product Description

(+)-Thalidomide

  • Synonym: R-(+)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

    • Empirical Formula (Hill Notation): C13H10N2O4

    • Molecular Weight: 258.23

    • CAS Number: 2614-06-4

 

assay  


98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: soluble15 mg/mL, clear
originator   Celgene
storage temp.   room temp
Gene Information   human ... LITAF(9516), TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)

Description

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

Preparation Note

Thalidomide is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml. It is insoluble in ethanol and water.

Application

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis[1]. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos[2].

Features and Benefits

This compound was developed by Celgene.

 

Trade Information
  • Payment Terms
  • Cash in Advance (CID), Cash Advance (CA)
  • Supply Ability
  • 500 Kilograms KG Per Month
  • Delivery Time
  • 2-8 Week
  • Sample Available
  • Yes
  • Sample Policy
  • Sample costs shipping and taxes has to be paid by the buyer
  • Packaging Details
  • Carton and Poly Bag.
  • Main Export Market(s)
  • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
  • Main Domestic Market
  • All India

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