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(−)-Thalidomide

(−)-Thalidomide
(−)-Thalidomide
Product Code : 571
Product Description

()-Thalidomide

  • Synonym: S()-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

    • Empirical Formula (Hill Notation): C13H10N2O4

    • Molecular Weight: 258.23

    • CAS Number: 841-67-8

 assay  


>98%
form   solid
optical activity   [α]23/D 62.6°, c = 2 in DMF(lit.)
color   white
solubility   DMSO: soluble
  H2O: insoluble
  ethanol: insoluble
originator   Celgene
Gene Information   human ... LITAF(9516), TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)

Description

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α); inhibitor of angiogenesis. (S)-Thalidomide is a teratogenic enatiomer.

Packaging

10 mg in poly bottle

25, 100 mg in glass bottle

Preparation Note

(-)-Thalidomide is soluble in DMSO, but is insoluble in water and ethanol.

Application

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis[1]. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos[2].

Features and Benefits

This compound was developed by Celgene.

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