|Home||» Products||» Biochemical & Reagents||» (Z)-4-Hydroxytamoxifen|
|protect from light|
|solubility||methanol: soluble10 mg/mL|
|ethanol: soluble20 mg/mL (with heating)|
|Gene Information|| human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569)|
rat ... Ar(24208), Esr1(24890), Esr2(25149)
5, 25 mg in glass bottle
4-Hydroxytamoxifen (4-HT) is the active metabolite of tamoxifen which binds estrogen receptors (ER) and estrogen-related receptors (ERR) with estrogenic and anti-estrogenic effects. It is a cell permeable, selective estrogen receptor modulator (SERM). In Cas9 variants engineered with ligand-dependent inteins 4-Hydroxytamoxifen was used control Cas9 function, which reduced off target effects in CRISPR-mediated gene editing.
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