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(Z)-4-Hydroxytamoxifen

(Z)-4-Hydroxytamoxifen
(Z)-4-Hydroxytamoxifen
Product Code : 614
Product Description
Quality Level  

PREMIUM
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
  protect from light
solubility   methanol: soluble10 mg/mL
  ethanol: soluble20 mg/mL (with heating)
originator   AstraZeneca
storage temp.   2-8°C
Gene Information   human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569)
rat ... Ar(24208), Esr1(24890), Esr2(25149)

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

4-Hydroxytamoxifen (4-HT) is the active metabolite of tamoxifen which binds estrogen receptors (ER) and estrogen-related receptors (ERR) with estrogenic and anti-estrogenic effects. It is a cell permeable, selective estrogen receptor modulator (SERM). In Cas9 variants engineered with ligand-dependent inteins 4-Hydroxytamoxifen was used control Cas9 function, which reduced off target effects in CRISPR-mediated gene editing.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids)

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