Cookie Img
Home » Products » Biochemical & Reagents » 12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
Product Code : 794
Product Description

12(S)-Hydroxy-(5z,8z,10e,14z)-Eicosatetraenoic Acid

  • Synonym: (S)-12-HETE

    • Empirical Formula (Hill Notation): c20h32o3

    • Molecular Weight: 320.47

    • Cas Number: 54397-83-0

Properties



Assay  

≥95% (HPLC)

Concentration  

~100 μg/mL In Ethanol

Shipped In  

Dry Ice

Storage Temp.  

−20°C


Description

Biochem/Physiol Actions

Prometastatic Metabolite Of Arachidonic Acid Via The 12-Lipoxygenase Pathway That Is Expressed In Many Tumor Cell Lines. It Is Produced In Coronary Microvasculature And Is A Potent Inducer Of Relaxation And Hyperpolarization Of These Microvessels. It Activates Large-Conductance Ca2+-Activated K+ Currents In Coronary Microvascular Smooth Muscle.

12(S)-Hete Is A Bioactive Lipid Implicated In Angiogenesis, Growth, And Metastasic Action In Tumor Cell Lines And In Animal Models. Arachidonate 12-Lipoxygenase (12-LOX) Converts Arachidonic Acid To 12(S)-(Hete). Alteration In 12-Lox Expression Or Activity Has Been Reported In Various Carcinomas Including Prostate Carcinoma.

Packaging

Packaged Under Argon.

Other Notes

Tandem Mass Spectrometry Data Independently Generated By Scripps Center For Metabolomics Is Available To View Or Download In Pdf. H7768.Pdf Tested Metabolites Are Featured On Scripps Center For Metabolomics Metlin Metabolite Database. To Learn More, Visit Sigma.Com/Metlin.




NATIONAL ANALYTICAL CORPORATION - CHEMICAL DIVISION


NATIONAL ANALYTICAL CORPORATION All Rights Reserved.