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(2S,3S)-Hydroxybupropion hydrochloride

(2S,3S)-Hydroxybupropion hydrochloride
(2S,3S)-Hydroxybupropion hydrochloride
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Product Code : 584
Product Description

(2S,3S)-Hydroxybupropion hydrochloride

  • Synonym: (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride, (2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride, (2S,3S)-Hydroxybupropion hydrochloride, GW 353162, Radafaxine hydrochloride, SS-hydroxybupropion hydrochloride

    • Empirical Formula (Hill Notation): C13H18ClNO2 · HCl

    • Molecular Weight: 292.20

    • CAS Number: 106083-71-0

assay  

98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: 12 mg/mL
storage temp.   20°C

Description

Biochem/physiol Actions

(2S,3S)-hydroxybupropion is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. (2S,3S)-hydroxybupropion is a major metabolite of bupropion. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in -dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of  reward in mice.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction.

 


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