(S)-(−)-Sulpiride

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(S)-(−)-Sulpiride

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Product Code : 609

Product Description

(S)-(âˆ’)-Sulpiride

Synonym: (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, Levosulpiride
- Empirical Formula (Hill Notation): C₁₅H₂₃N₃O₄S
- Molecular Weight: 341.43
- CAS Number: 23672-07-3

assay

	â‰¥98% (titration)
mp	183-186 °C(lit.)
originator	Sanofi Aventis
storage temp.	2-8°C
Gene Information	human ... DRD2(1813), DRD3(1814) rat ... Adra1a(29412), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595)

Description

Biochem/physiol Actions

D₂ dopamine receptor antagonist; antipsychotic.

(S)-(âˆ’)-Sulpiride or Levosulpiride blocks the inhibitory enteric D₂ receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.^7,8 Since dopamine controls human sexual function, (S)-(âˆ’)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.⁹

Packaging

5, 10 g in poly bottle

Application

(S)-(âˆ’)-Sulpiride was used to study the effect of dopamine D₂ receptor function on activation of KCNQ potassium channels¹⁰ and on depression-like behavior in ovariectomized female rats.¹¹

Features and Benefits

This compound is also offered as part of Sigmaâ€²s Library of Pharmacologically Active Compounds (LOPAC^®¹²⁸⁰), a biologically annotated collection of high-quality, ready-to-screen compounds.

This compound was developed by Sanofi Aventis