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(S)-(−)-Sulpiride

(S)-(−)-Sulpiride
(S)-(−)-Sulpiride
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Product Code : 609
Product Description

(S)-(−)-Sulpiride

  • Synonym: (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, Levosulpiride

    • Empirical Formula (Hill Notation): C15H23N3O4S

    • Molecular Weight: 341.43

    • CAS Number: 23672-07-3

assay  

≥98% (titration)
mp   183-186 °C(lit.)
originator   Sanofi Aventis
storage temp.   2-8°C
Gene Information   human ... DRD2(1813), DRD3(1814)
rat ... Adra1a(29412), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595)

Description

Biochem/physiol Actions

D2 dopamine receptor antagonist; antipsychotic.

(S)-(−)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(−)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9

Packaging

5, 10 g in poly bottle

Application

(S)-(−)-Sulpiride was used to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels10 and on depression-like behavior in ovariectomized female rats.11

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. 

This compound was developed by Sanofi Aventis

 


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