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Synonym: (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, Levosulpiride
Empirical Formula (Hill Notation): C15H23N3O4S
Molecular Weight: 341.43
CAS Number: 23672-07-3
≥98% (titration) | |
mp | 183-186 °C(lit.) |
originator | Sanofi Aventis |
storage temp. | 2-8°C |
Gene Information | human ... DRD2(1813), DRD3(1814) rat ... Adra1a(29412), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595) |
D2 dopamine receptor antagonist; antipsychotic.
(S)-(−)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(−)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9
5, 10 g in poly bottle
(S)-(−)-Sulpiride was used to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels10 and on depression-like behavior in ovariectomized female rats.11
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds.
This compound was developed by Sanofi Aventis
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