Cavitron cyclodextrin and CAVASOL cyclodextrin

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Cavitron cyclodextrin and CAVASOL cyclodextrin Specification

Density
1.5 Gram per cubic centimeter(g/cm3)

Melting Point
>300 C (decomposes)

CAS No
7585-39-9

Molecular Weight
1135 g/mol

Packaging Type
Drum, Bag

Physical State
Powder

Usage
Complexing agent, solubility enhancer, stabilizer

Storage Instructions
Store in a cool, dry place, tightly closed

Size
Customizable, standard 1 kg/25 kg packs

Shelf Life
3 years

Ph Level
5.0 8.0 (1% solution)

Molecular Formula
C42H70O35

Purity
99%

Grade
Pharmaceutical Grade

Type
Cyclodextrin

Application
Pharmaceutical, Food, Cosmetic

Appearance
White Crystalline Powder

Purity(%)
99%

Cavitron cyclodextrin and CAVASOL cyclodextrin Trade Information

Minimum Order Quantity
1 Piece

Payment Terms
Cash in Advance (CID), Cash Advance (CA)

Supply Ability
3 Pieces Per Week

Main Export Market(s)
Western Europe, Australia, North America, South America, Eastern Europe, Middle East, Central America, Asia, Africa

About Cavitron cyclodextrin and CAVASOL cyclodextrin

Cavitron and CAVASOL hydroxypropyl-A- and hydroxypropyl-I3-cyclodextrins (HPBCD and HPGCD)

Chemistry: Cyclodextrins

The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-A- or hydroxypropyl-I3-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the Cavitron and CAVASOL HPBCDs and HPGCDs capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation, and also can increase solubility of poorly soluble compounds in oral drug delivery systems. Purification of the Cavitron cyclodextrins to remove endotoxins allows their use for solubilization of drugs for parenteral drug products.

The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package, now called PRD, and the Certificate of Analysis (COA).

Superior Solubility and Stability

Cavitron and CAVASOL cyclodextrin are freely soluble in water but only slightly soluble in ethanol, making them ideal for use as solubility enhancers. They retain stability under recommended storage conditions, guaranteeing consistent performance and shelf-life of up to three years when stored tightly closed in a cool, dry environment.

Pharmaceutical Grade Quality

With a laboratory-tested purity of over 99% by HPLC and compliance with stringent pharmaceutical grade requirements, Cavitron/CAVASOL cyclodextrin ensures minimal heavy metals (5 ppm), low ash and endotoxin levels, and is produced to meet standard pharmacopeia microbial limits. This meticulous attention to quality ensures suitability for sensitive applications.

Versatile Applications and Easy Handling

Their white crystalline powder form, customizable sizes (standard 1 kg/25 kg), and long shelf-life make these cyclodextrins easy to handle and incorporate into a wide range of applications, from solubilizing agents in pharmaceuticals to stabilizers in food and cosmetics industries. The slightly sweet taste and odorless nature further expand their usability.

FAQ's of Cavitron cyclodextrin and CAVASOL cyclodextrin:

Q: How is Cavitron/CAVASOL cyclodextrin used in pharmaceutical formulations?

A: Cavitron/CAVASOL cyclodextrin is primarily utilized as a complexing agent and solubility enhancer. It helps increase the aqueous solubility of poorly soluble drugs, improves their stability, and can mask undesirable tastes, making pharmaceutical formulations more effective and palatable.

Q: What benefits do Cavitron and CAVASOL cyclodextrins offer in food and cosmetics?

A: These cyclodextrins act as stabilizers, flavor carriers, and solubility enhancers in food and cosmetic products. Their odorless and slightly sweet profile, combined with low toxicity and high purity, allow for enhanced ingredient delivery and product stability without altering taste or scent profiles.

Q: When should Cavitron/CAVASOL cyclodextrin be stored for optimal effectiveness?

A: For best results, Cavitron/CAVASOL cyclodextrin should be stored tightly closed in a cool, dry environment-preferably in the original packaging. This ensures product stability, maintains purity, and maximizes the three-year shelf life.

Q: Where are Cavitron and CAVASOL cyclodextrins typically sourced and how are they packaged?

A: These cyclodextrins are supplied and traded by reputable pharmaceutical and ingredient providers. They are commonly available in standard packaging of 1 kg or 25 kg drums or bags, though custom sizes can be arranged to meet specific bulk or laboratory needs.

Q: What is the recommended process for incorporating Cavitron/CAVASOL cyclodextrin into a formulation?

A: Cavitron/CAVASOL cyclodextrin is most effective when dissolved in water, given its high solubility in aqueous media. It should be added to formulations under controlled conditions to ensure homogeneity and maximize its ability to encapsulate and stabilize target molecules.

Q: Are there any handling precautions or storage requirements for Cavitron/CAVASOL cyclodextrin?

A: It is important to keep the product tightly closed in its container and store it in a cool, dry place. This prevents moisture uptake and protects the physical and chemical stability of the cyclodextrin over its intended shelf life.

Q: What makes Cavitron/CAVASOL cyclodextrin suitable for sensitive applications?

A: The high purity (over 99%), very low heavy metal and endotoxin contents, compliance with standard pharmacopeia microbial limits, and stable crystalline nature make these cyclodextrins particularly suited for use in sensitive pharmaceutical, food, and cosmetic formulations.

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