About Chlorotrimethylsilane 98.0%
Chlorotrimethylsilane
98.0% (GC)
Synonym: TMCS, Trimethylchlorosilane, Trimethylsilyl chloride
General description
Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.
Application
Chlorotrimethylsilane has been used to silanize glass surface to make them more hydrophobic.It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation reaction.Also used in Fisher Glycosylation
| vapor density | 3.7 (vs air) |
| vapor pressure | 100 mmHg ( 25 C) |
| assay | 98.0% (GC) |
| autoignition temp. | 752 F |
| expl. lim. | 6.4 % |
| refractive index | n20/D 1.387 (lit.) |
| bp | 57 C (lit.) |
| mp | 40 C (lit.) |
| density | 0.856 g/mL at 25 C (lit.) |
Key Applications and VersatilityChlorotrimethylsilane is widely utilized as a silylation reagent, aiding the protection of functional groups during organic synthesis. Its role as a pharmaceutical intermediate makes it essential for chemical manufacturing. With high purity and solubility in organic solvents, it ensures efficient reactions in laboratory and industrial settings.
Safe Handling and StorageThis chemical is highly moisture sensitive and flammable, necessitating storage in cool, dry places with containers tightly closed. Avoid contact with water and strong oxidizing agents to maintain stability. Its shelf life of 24 months guarantees usability when following proper storage guidelines.
FAQ's of Chlorotrimethylsilane 98.0%:
Q: How should Chlorotrimethylsilane be stored to maintain its stability and shelf life?
A: It should be stored in a cool, dry area in tightly sealed containers, away from moisture, water, and strong oxidizing agents. Adhering to these storage instructions ensures a shelf life of up to 24 months and preserves product integrity.
Q: What is the main usage of Chlorotrimethylsilane in industrial applications?
A: Chlorotrimethylsilane is primarily used as a silylating agent in organic synthesis and as an intermediate in pharmaceutical manufacturing. Its ability to introduce silyl groups aids in protecting sensitive functional groups during chemical reactions.
Q: When is it necessary to avoid using Chlorotrimethylsilane with certain chemicals?
A: Avoid using Chlorotrimethylsilane in the presence of water and strong oxidizing agents, as it reacts vigorously with moisture and may cause hazardous conditions. Compatibility considerations are crucial for safe procedures.
Q: Where is Chlorotrimethylsilane typically supplied and packaged?
A: This compound is supplied in India, offered by traders and suppliers, and is available in various packaging options such as sealed drums or bottles. Sizes can be customized based on requirements for laboratory or industrial use.
Q: What are the processing considerations when working with Chlorotrimethylsilane?
A: Due to its high moisture sensitivity and flammability, handle Chlorotrimethylsilane under dry, inert conditions, preferably inside a fume hood. Use appropriate protective equipment and ensure good ventilation during processing.
Q: What benefits does Chlorotrimethylsilane offer in chemical synthesis?
A: Its high purity and reactivity make it highly effective for introducing trimethylsilyl groups, enhancing the efficiency and selectivity of organic syntheses, particularly in pharmaceutical and specialty chemical manufacturing.