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(±)-DOI hydrochloride

(±)-DOI hydrochloride
(±)-DOI hydrochloride
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Product Code : 522
Product Description

(±)-DOI hydrochloride

 

  • Synonym: (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride, (±)-DOI

    • Empirical Formula (Hill Notation): C11H16INO2 · HCl

    • Molecular Weight: 357.62

    • CAS Number: 42203-78-1

 assay  


≥98% (HPLC)
form   solid
drug control   Home Office Schedule 1
  regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to off-white
solubility   H2O: soluble10 mg/mL
  ethanol: soluble2 mg/mL
Gene Information   human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Description

Packaging

10 mg in glass bottle

25 mg in poly bottle

100, 500 mg in glass bottle

Biochem/physiol Actions

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

 

 


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