Synonym: ()-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, ()-2,5-Dimethoxy-4-iodoamphetamine hydrochloride, ()-DOI
Empirical Formula (Hill Notation): C11H16INO2 HCl
Molecular Weight: 357.62
CAS Number: 42203-78-1
|drug control||Home Office Schedule 1|
|regulated under CDSA - not available from Sigma-Aldrich Canada|
|color||white to off-white|
|solubility||H2O: soluble10 mg/mL|
|ethanol: soluble2 mg/mL|
|Gene Information||human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)|
10 mg in glass bottle
25 mg in poly bottle
100, 500 mg in glass bottle
()-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.
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