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| Home | » Products | » Biochemical & Reagents | » (±)-DOI hydrochloride |
Synonym: (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride, (±)-DOI
Empirical Formula (Hill Notation): C11H16INO2 · HCl
Molecular Weight: 357.62
CAS Number: 42203-78-1
assay
| ≥98% (HPLC) | |
| form | solid |
| drug control | Home Office Schedule 1 |
| regulated under CDSA - not available from Sigma-Aldrich Canada | |
| color | white to off-white |
| solubility | H2O: soluble10 mg/mL |
| ethanol: soluble2 mg/mL | |
| Gene Information | human ... HTR2A(3356), HTR2B(3357), HTR2C(3358) |
10 mg in glass bottle
25 mg in poly bottle
100, 500 mg in glass bottle
(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.
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