(±)-DOI hydrochloride

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Product Code : 522

Product Description

(±)-DOI hydrochloride

Synonym: (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride, (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride, (±)-DOI
- Empirical Formula (Hill Notation): C₁₁H₁₆INO₂ · HCl
- Molecular Weight: 357.62
- CAS Number: 42203-78-1

assay

	â‰¥98% (HPLC)
form	solid
drug control	Home Office Schedule 1
	regulated under CDSA - not available from Sigma-Aldrich Canada
color	white to off-white
solubility	H₂O: soluble10 mg/mL
	ethanol: soluble2 mg/mL
Gene Information	human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)

Description

Packaging

10 mg in glass bottle

25 mg in poly bottle

100, 500 mg in glass bottle

Biochem/physiol Actions

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.