(±)-α-Methyl-(4-tetrazolylphenyl)glycine

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Product Code : 515

Product Description

(±)-Î±-Methyl-(4-tetrazolylphenyl)glycine

- Empirical Formula (Hill Notation): C₁₀H₁₁N₅O₂
- Molecular Weight: 233.23
- CAS Number: 169209-66-9

storage temp.

2-8°C

Description

Biochem/physiol Actions

(±)-Î±-Methyl-(4-tetrazolylphenyl)glycine (MTPG) was used in rat models of cerebral ischemia to explore the role of group II metabotropic glutamate receptors mGluR2/3 in brain ischemia tolerance. MTPG inhibited the induction of ischemia tolerance indicating the involvement of mGluR2/3 in the induction of the protective mechanism. ^[1]

Potent antagonist for (1S,3S)-ACPD-sensitive receptors; preference for GluR₂ and GluR₃ subtypes