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(S)-(+)-Camptothecin

(S)-(+)-Camptothecin

100 Onwards INR

Product Details:

  • Molecular Formula C20H16N2O4
  • Molecular Weight 348.352 Grams (g)
  • Melting Point 275 to 277 C (527 to 531 F)
  • Usage As a result of these efforts, two camptothecin analogs have been approved for cancer therapy: Topotecan (hycamtin) is approved for the treatment of recurring ovarian cancer, small cell lung cancer, and in combination with cisplatin for cervical cancer; irinotecan (camptosar) is prescribed for advanced cancers of the ...
  • Boiling point 757.060.0 C at 760 mmHg
  • Chemical Name Camptothecin
  • Supply Ability : 500 Kilograms KG Per Month
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Price And Quantity

  • 1 Kilograms
  • 100 Onwards INR

Product Specifications

  • C20H16N2O4
  • Camptothecin
  • 348.352 Grams (g)
  • 757.060.0 C at 760 mmHg
  • As a result of these efforts, two camptothecin analogs have been approved for cancer therapy: Topotecan (hycamtin) is approved for the treatment of recurring ovarian cancer, small cell lung cancer, and in combination with cisplatin for cervical cancer; irinotecan (camptosar) is prescribed for advanced cancers of the ...
  • 275 to 277 C (527 to 531 F)

Trade Information

  • Cash Advance (CA), Cash in Advance (CID)
  • 500 Kilograms KG Per Month
  • 2-8 Week
  • Yes
  • Sample costs shipping and taxes has to be paid by the buyer
  • Carton and Poly Bag.
  • Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
  • All India

Product Description

(S)-(+)-Camptothecin


    • Empirical Formula (Hill Notation): C20H16N2O4

    • Molecular Weight: 348.35

    • CAS Number: 7689-03-4

      assay  


      90% (HPLC)
      form   powder
      mp   260 C (dec.)(lit.)
      solubility   chloroform/methanol (4:1): soluble5 mg/mL
      Mode of action   DNA synthesis | interferes
        enzyme | inhibits
      storage temp.   2-8C
      Gene Information   human ... TOP1(7150)
      mouse ... Prkca(18750)
      rat ... Sstr2(54305)

      Description

      Other Notes

      20S isomer

      Packaging

      1 g in glass bottle

      100, 250 mg in glass bottle

      Biochem/physiol Actions

      (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.

      Features and Benefits

      This compound is a featured product for Apoptosis research.

       

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