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(S)-(+)-Camptothecin

(S)-(+)-Camptothecin
(S)-(+)-Camptothecin
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Product Code : 604
Product Description

(S)-(+)-Camptothecin


    • Empirical Formula (Hill Notation): C20H16N2O4

    • Molecular Weight: 348.35

    • CAS Number: 7689-03-4

      assay  


      ≥90% (HPLC)
      form   powder
      mp   260 °C (dec.)(lit.)
      solubility   chloroform/methanol (4:1): soluble5 mg/mL
      Mode of action   DNA synthesis | interferes
        enzyme | inhibits
      storage temp.   2-8°C
      Gene Information   human ... TOP1(7150)
      mouse ... Prkca(18750)
      rat ... Sstr2(54305)

      Description

      Other Notes

      20S isomer

      Packaging

      1 g in glass bottle

      100, 250 mg in glass bottle

      Biochem/physiol Actions

      (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.

      Features and Benefits

      This compound is a featured product for Apoptosis research.

       


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