|Home||» Products||» Biochemical & Reagents||» (−)-Thalidomide|
Empirical Formula (Hill Notation): C13H10N2O4
Molecular Weight: 258.23
CAS Number: 841-67-8
|optical activity||[Î±]23/D 62.6°, c = 2 in DMF(lit.)|
|Gene Information|| human ... LITAF(9516), TNF(7124)|
mouse ... Nos2(18126)
rat ... Nos1(24598)
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor Î± (TNF-Î±); inhibitor of angiogenesis. (S)-Thalidomide is a teratogenic enatiomer.
10 mg in poly bottle
25, 100 mg in glass bottle
(-)-Thalidomide is soluble in DMSO, but is insoluble in water and ethanol.
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.