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(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate
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Product Code : 572
Product Description

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate

  • Synonym: trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate

    • Empirical Formula (Hill Notation): C19H26Cl2N2O · HCl · xH2O

    • Molecular Weight: 405.79 (anhydrous basis)

    • CAS Number: 114528-79-9 (anhydrous)

 ssay  


≥98% (HPLC)
form   solid
optical activity   [α]22/D −36.05°, c = 0.73 in methanol(lit.)
storage condition   desiccated
color   white
solubility   H2O: soluble13 mg/mL
storage temp.   2-8°C
Gene Information   human ... OPRK1(4986)

Description

Biochem/physiol Actions

Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.

Preparation Note

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate is soluble in water at 13 mg/ml.

Application

(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta)[1].

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds.

NATIONAL ANALYTICAL CORPORATION - CHEMICAL DIVISION

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