(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate

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Product Code : 572

Product Description

(âˆ’)-trans-(1S,2S)-U-50488 hydrochloride hydrate

Synonym: trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate
- Empirical Formula (Hill Notation): C₁₉H₂₆Cl₂N₂O · HCl · xH₂O
- Molecular Weight: 405.79 (anhydrous basis)
- CAS Number: 114528-79-9 (anhydrous)

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	â‰¥98% (HPLC)
form	solid
optical activity	[Î±]22/D âˆ’36.05°, c = 0.73 in methanol(lit.)
storage condition	desiccated
color	white
solubility	H₂O: soluble13 mg/mL
storage temp.	2-8°C
Gene Information	human ... OPRK1(4986)

Description

Biochem/physiol Actions

Potent Îº opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.

Preparation Note

(âˆ’)-trans-(1S,2S)-U-50488 hydrochloride hydrate is soluble in water at 13 mg/ml.

Application

(âˆ’)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a Îº-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta)^[1].

Features and Benefits

This compound is also offered as part of Sigmaâ€²s Library of Pharmacologically Active Compounds (LOPAC^®¹²⁸⁰), a biologically annotated collection of high-quality, ready-to-screen compounds.