Synonym: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
Linear Formula: (CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
Molecular Weight: 491.06
CAS Number: 152-11-4
|mp||142 °C (dec.)(lit.)|
|solubility||methanol: soluble50 mg/mL|
|Gene Information||human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)|
1, 5, 10 g in glass bottle
±1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
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This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction.