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Synonym: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
Linear Formula: (CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
Molecular Weight: 491.06
CAS Number: 152-11-4
|mp||142 °C (dec.)(lit.)|
|solubility||methanol: soluble50 mg/mL|
|Gene Information||human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)|
1, 5, 10 g in glass bottle
±1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
This compound is a featured product for ADME Tox research.
This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC), a biologically annotated collection of high-quality, ready-to-screen compounds.
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction.