(±)-Verapamil hydrochloride

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Product Code : 540

Product Description

(±)-Verapamil hydrochloride

Synonym: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride

Linear Formula: (CH₃O)₂C₆H₃CH₂CH₂N(CH₃)(CH₂)₃C[C₆H₃(OCH₃)₂][CH(CH₃)₂]CN · HCl
Molecular Weight: 491.06

CAS Number: 152-11-4

assay

	¥99% (titration)
form	powder
color	white
mp	142 °C (dec.)(lit.)
solubility	methanol: soluble50 mg/mL
	ethanol: soluble
originator	Pfizer
Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

Packaging

1, 5, 10 g in glass bottle

Biochem/physiol Actions

±₁-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca²⁺ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.

Features and Benefits

This compound is a featured product for ADME Tox research.

This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC), a biologically annotated collection of high-quality, ready-to-screen compounds.

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction.

This compound was developed by Pfizer.