12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

About 12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

12(S)-Hydroxy-(5z,8z,10e,14z)-Eicosatetraenoic Acid Synonym: (S)-12-HETE Empirical Formula (Hill Notation): c20h32o3 Molecular Weight: 320.47 Cas Number: 54397-83-0 Properties Assay 95% (HPLC) Concentration 100g/mL In Ethanol Shipped In Dry Ice Storage Temp. 20 Degree C Description Biochem/Physiol Actions Prometastatic Metabolite Of Arachidonic Acid Via The 12-Lipoxygenase Pathway That Is Expressed In Many Tumor Cell Lines. It Is Produced In Coronary Microvasculature And Is A Potent Inducer Of Relaxation And Hyperpolarization Of These Microvessels. It Activates Large-Conductance Ca2+-Activated K+ Currents In Coronary Microvascular Smooth Muscle. 12(S)-Hete Is A Bioactive Lipid Implicated In Angiogenesis, Growth, And Metastasic Action In Tumor Cell Lines And In Animal Models. Arachidonate 12-Lipoxygenase (12-LOX) Converts Arachidonic Acid To 12(S)-(Hete). Alteration In 12-Lox Expression Or Activity Has Been Reported In Various Carcinomas Including Prostate Carcinoma. Packaging Packaged Under Argon. Other Notes Tandem Mass Spectrometry Data Independently Generated By Scripps Center For Metabolomics Is Available To View Or Download In Pdf. H7768.Pdf Tested Metabolites Are Featured On Scripps Center For Metabolomics Metlin Metabolite Database. To Learn More, Visit Sigma.Com/Metlin.