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17-(Allylamino)-17-demethoxygeldanamycin

17-(Allylamino)-17-demethoxygeldanamycin

Product Details:

  • Melting Point 201-203C
  • Molecular Weight ‎585.7 Grams (g)
  • Molecular Formula ‎C31H43N3O8
  • Chemical Name 17-(Allylamino)-17-demethoxygeldanamycin
  • Purity(%) 98%
  • Supply Ability : 500 Kilograms Per Month
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Price And Quantity

  • 100 INR
  • 1 Kilograms

Product Specifications

  • 201-203C
  • 17-(Allylamino)-17-demethoxygeldanamycin
  • ‎C31H43N3O8
  • ‎585.7 Grams (g)
  • 98%

Trade Information

  • Cash Advance (CA), Cash in Advance (CID)
  • 500 Kilograms Per Month
  • 3-4 Week
  • Yes
  • Sample costs shipping and taxes has to be paid by the buyer
  • Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
  • All India

Product Description

17-(Allylamino)-17-demethoxygeldanamycin

    Synonym: 17-(Allylamino)geldanamycin, 17-AAG, 17-Demethoxy-17-allylamino geldanamycin, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin

  • Empirical Formula (Hill Notation): C31H43N3O8
  • Molecular Weight: 585.69
  • CAS Number: 75747-14-7
  • 98% (HPLC), solid  

Properties
Related Categories     A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents, More...

  • assay   :   98% (HPLC)
  • form    :   solid
  • solubility    :   DMSO: soluble
  • methanol: soluble
  • Mode of action  :     enzyme | inhibits
  • shipped in   :    wet ice
  • storage temp.   :    20C

Description
Biochem/physiol Actions


Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
Packaging

500 g in glass bottle

Application

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

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