17- (Allylamino)-17-demethoxygeldanamycin

About 17- (Allylamino)-17-demethoxygeldanamycin

17-(Allylamino)-17-demethoxygeldanamycin Synonym: 17-(Allylamino)geldanamycin, 17-AAG, 17-Demethoxy-17-allylamino geldanamycin, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, TanespimycinEmpirical Formula (Hill Notation): C31H43N3O8Molecular Weight: 585.69CAS Number: 75747-14-798% (HPLC), solid PropertiesRelated Categories A-AM, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antitumor Agents, More...assay : 98% (HPLC)form : solidsolubility : DMSO: solublemethanol: solubleMode of action : enzyme | inhibitsshipped in : wet icestorage temp. : 20 Degree CDescriptionBiochem/physiol ActionsPotent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.Packaging500 g in glass bottleApplication17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.