2,5-Dimethyl-celecoxib

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Product Code : 562

Price And Quantity

Minimum Order Quantity
1
Unit of Measure
Kilograms/Kilograms

Price Range
500.00 - 1500.00 USD ($)

Product Specifications

Purity
98%
Molecular Formula
C18H16F3N3O2S

Molecular Weight
395.4 Grams (g)
Physical Form
Powder

Solubility
‎DMSO: 20 mg/mL
Usage
Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.

Product Description

2,5-Dimethyl-celecoxib

VETRANAL^™, analytical standard

Synonym: 2,5-Dimethylcelecoxib, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

CAS Number 457639-26-8

Empirical Formula (Hill Notation) C₁₈H₁₆F₃N₃O₂S

Molecular Weight 395.40

grade	analytical standard
product line	VETRANAL^™
form	neat
application(s)	HPLC: suitable
	gas chromatography (GC): suitable
format	neat

Biochem/physiol Actions

Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

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