2,5-Dimethyl-celecoxib

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Product Code : 562

Product Description

2,5-Dimethyl-celecoxib

VETRANAL^™, analytical standard

Synonym: 2,5-Dimethylcelecoxib, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

CAS Number 457639-26-8

Empirical Formula (Hill Notation) C₁₈H₁₆F₃N₃O₂S

Molecular Weight 395.40

grade	analytical standard
product line	VETRANAL^™
form	neat
application(s)	HPLC: suitable
	gas chromatography (GC): suitable
format	neat

Biochem/physiol Actions

Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.