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Home » Products » Analytical Grade Chemicals » 2,5-Dimethyl-celecoxib

2,5-Dimethyl-celecoxib

2,5-Dimethyl-celecoxib
2,5-Dimethyl-celecoxib
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Product Code : 562
Price And Quantity
  • Minimum Order Quantity
  • 1 Kilograms
  • Price
  • 100 Onwards INR
Product Specifications
  • Molecular Formula
  • C18H16F3N3O2S
  • Usage
  • Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.
  • Solubility
  • DMSO: 20 mg/mL
  • Molecular Weight
  • 395.4 Grams (g)
  • Physical Form
  • Powder
  • Purity
  • 98%
Product Description

2,5-Dimethyl-celecoxib

VETRANAL™, analytical standard

Synonym: 2,5-Dimethylcelecoxib, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

  • CAS Number 457639-26-8
  • Empirical Formula (Hill Notation) C18H16F3N3O2S
  • Molecular Weight 395.40

    •  

    grade   analytical standard
    product line   VETRANAL™
    form   neat
    application(s)   HPLC: suitable
      gas chromatography (GC): suitable
    format   neat

    Biochem/physiol Actions

    Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

     

    Trade Information
    • Payment Terms
    • Cash in Advance (CID), Cash Advance (CA)
    • Supply Ability
    • 500 Kilograms KG Per Month
    • Delivery Time
    • 2-8 Week
    • Sample Available
    • Yes
    • Sample Policy
    • Sample costs shipping and taxes has to be paid by the buyer
    • Packaging Details
    • Carton and Poly Bag.
    • Main Export Market(s)
    • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
    • Main Domestic Market
    • All India

    NATIONAL ANALYTICAL CORPORATION - CHEMICAL DIVISION

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