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Home | » Products | » Analytical Grade Chemicals | » 2,5-Dimethyl-celecoxib |
Synonym: 2,5-
grade | analytical standard |
product line | VETRANAL™ |
form | neat |
application(s) | HPLC: suitable |
gas chromatography (GC): suitable | |
format | neat |
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
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