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2,5-Dimethyl-celecoxib

2,5-Dimethyl-celecoxib
2,5-Dimethyl-celecoxib
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Product Code : 562
Product Description

2,5-Dimethyl-celecoxib

VETRANAL, analytical standard

Synonym: 2,5-Dimethylcelecoxib, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

  • CAS Number 457639-26-8
  • Empirical Formula (Hill Notation) C18H16F3N3O2S
  • Molecular Weight 395.40
  •  

    grade   analytical standard
    product line   VETRANAL
    form   neat
    application(s)   HPLC: suitable
      gas chromatography (GC): suitable
    format   neat

    Biochem/physiol Actions

    Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

     


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