2,5-Dimethyl-celecoxib

100 Onwards INR

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Product Details:

Usage Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.
Purity 98%
Physical Form Powder
Molecular Formula C18H16F3N3O2S
Solubility DMSO: 20 mg/mL
Molecular Weight 395.4 Grams (g)
Supply Ability : 500 Kilograms KG Per Month
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Price And Quantity

Price 100 Onwards INR
Minimum Order Quantity 1 Kilograms

Product Specifications

Solubility DMSO: 20 mg/mL
Molecular Weight 395.4 Grams (g)
Molecular Formula C18H16F3N3O2S
Physical Form Powder
Usage Celecoxib, sold under the brand name Celebrex among others, is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.
Purity 98%

Trade Information

Payment Terms Cash Advance (CA), Cash in Advance (CID)
Supply Ability 500 Kilograms KG Per Month
Delivery Time 2-8 Week
Sample Available Yes
Sample Policy Sample costs shipping and taxes has to be paid by the buyer
Packaging Details Carton and Poly Bag.
Main Export Market(s) Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
Main Domestic Market All India

Product Description

2,5-Dimethyl-celecoxib

VETRANAL, analytical standard

Synonym: 2,5-Dimethylcelecoxib, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

CAS Number 457639-26-8

Empirical Formula (Hill Notation) C₁₈H₁₆F₃N₃O₂S

Molecular Weight 395.40

grade	analytical standard
product line	VETRANAL
form	neat
application(s)	HPLC: suitable
	gas chromatography (GC): suitable
format	neat

Biochem/physiol Actions

Celecoxib, and the inactive analog 2,5-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2,5-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

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