About 6-Amino-1- methyluracil
6-Amino-5-(N-methylformylamino)-1-methyluracil
Molecularformula: CHNO
CASnumber: 2434-53-9
Appearance:White to off-white powder
Meltingpoint: 240-242C
solubility:Soluble in water, methanol, ethanol, and acetone
Stability:Stable at room temperature
Toxicity:Low toxicity
6-Amino-1-methyluracilis a synthetic pyrimidine derivative that is used as a research tool inbiochemistry and molecular biology. It is also being investigated as apotential cancer treatment.
It is astructural analog of uracil, a natural pyrimidine base found in DNA and RNA.
It is acompetitive inhibitor of the enzyme thymidylate synthase, which is involved inDNA synthesis.
Thisinhibition can lead to cell death in cancer cells.
6-Amino-1-methyluracil is currently beinginvestigated in clinical trials for the treatment of leukemia and othercancers.Versatile Applications in Pharmaceuticals6-Amino-1-methyluracil is widely employed as an intermediate in pharmaceutical manufacturing and as a reagent in organic synthesis. Its high purity and compliance with pharmaceutical standards make it ideal for demanding research and development projects. Its use streamlines complex synthesis processes, supporting innovative drug discovery and chemical investigations.
Safe Handling and Robust StabilityThis compound is classified as non-hazardous and retains stable properties when stored between 2-8C in a cool, dry, well-ventilated environment. Its solid, crystalline nature and lack of hazardous codes ensure ease of transport, storage, and usage, giving laboratories and manufacturers peace of mind regarding both safety and quality.
FAQ's of 6-Amino-1- methyluracil:
Q: How should 6-Amino-1-methyluracil be stored for optimal stability?
A: For maximum shelf life and to maintain compound stability, 6-Amino-1-methyluracil should be stored at a temperature between 2C and 8C in a cool, dry, and well-ventilated area. Proper storage minimizes degradation and preserves its pharmaceutical-grade quality for up to two years.
Q: What is the primary usage of 6-Amino-1-methyluracil in the pharmaceutical industry?
A: 6-Amino-1-methyluracil serves mainly as an intermediate in the synthesis of pharmaceuticals. Its high purity and compliance with microbial limits make it suitable for research and manufacturing processes involved in drug development.
Q: Where is 6-Amino-1-methyluracil commonly applied outside pharmaceuticals?
A: Outside of pharmaceutical applications, this compound is also valued in chemical research and organic synthesis, where it participates as a building block in complex molecular constructions.
Q: What packaging options are available for 6-Amino-1-methyluracil?
A: The compound is typically supplied in HDPE drums or bottles, with the option for customized packaging to meet specific storage or transport requirements.
Q: How should 6-Amino-1-methyluracil be handled during the research process?
A: Given its non-hazardous status, standard laboratory safety procedures are sufficient. However, it is important to avoid inhalation and direct contact, using appropriate personal protective equipment as with any fine chemical.
Q: What is the benefit of using pharmaceutical grade 6-Amino-1-methyluracil?
A: Pharmaceutical grade ensures a high level of purity (98%) and compliance with industry standards, which reduces the risk of impurities that may interfere with chemical reactions or final product safety in pharmaceutical and research applications.