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· 6-Amino-5-(N-methylformylamino)-1-methyluracil
Molecularformula: C HNO
CASnumber: 2434-53-9
Appearance:White to off-white powder
Meltingpoint: 240-242C
solubility:Soluble in water, methanol, ethanol, and acetone
Stability:Stable at room temperature
Toxicity:Low toxicity
6-Amino-1-methyluracilis a synthetic pyrimidine derivative that is used as a research tool inbiochemistry and molecular biology. It is also being investigated as apotential cancer treatment.
It is astructural analog of uracil, a natural pyrimidine base found in DNA and RNA.
It is acompetitive inhibitor of the enzyme thymidylate synthase, which is involved inDNA synthesis.
Thisinhibition can lead to cell death in cancer cells.
6-Amino-1-methyluracil is currently beinginvestigated in clinical trials for the treatment of leukemia and othercancers.