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8-Methoxypsoralen

8-Methoxypsoralen
8-Methoxypsoralen
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Product Code : 1505
Product Description

8-Methoxypsoralen

analytical standard

Synonym: 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin

  • CAS Number 298-81-7

  • Empirical Formula (Hill Notation) C12H8O4

  • Molecular Weight 216.19

Properties



grade   analytical standard
form   neat
  powder
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   white to yellow
mp   148-150 °C(lit.)
solubility   H2O: slightly soluble
  acetic acid: soluble
format   neat
Gene Information   rat ... Maoa(29253)

Description

Biochem/physiol Actions

8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].

Caution

Protect from light.


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