About Klucel Hydroxypropylcellulose
Klucel Hydroxypropylcellulose
Chemistry: Cellulosics
Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermo plasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Ashland. Klucel HPC films are flexible without plasticizers and non-tacky at high humidity.
Superior Solubility and VersatilityKlucel Hydroxypropylcellulose stands out for its excellent solubility in water and alcohol and its adaptable viscosity range. These properties allow for flexible use in formulations requiring precise rheological control, making it highly valued in pharmaceutical, food, and personal care industries.
Broad Compatibility and PurityWith a purity of at least 99% and compatibility with most pharmaceutical actives, Klucel can be reliably used in diverse formulations. Its pharmaceutical grade ensures safe, stable, and high-performance excipient properties, making it a preferred choice in regulated industries.
FAQ's of Klucel Hydroxypropylcellulose:
Q: How do you dissolve Klucel Hydroxypropylcellulose for use in formulations?
A: Klucel Hydroxypropylcellulose dissolves readily in both water and alcohol. For optimal dissolution, gradually disperse the powder into the chosen solvent while stirring continuously to avoid clumping. The viscosity of the solution may vary based on the grade and concentration used.
Q: What are the main applications of Klucel Hydroxypropylcellulose?
A: Klucel serves primarily as a tablet binder, film former, and thickener in pharmaceutical formulations. Additionally, it is used as a stabilizer and thickener in personal care products and as a food additive for texture modification.
Q: When should Klucel be added during the manufacturing process?
A: Klucel can be introduced during the wet or dry granulation stage for tablet formulations or dispersed during the preparation of liquid or semi-solid products. Always ensure complete dispersion to achieve uniform consistency in the final product.
Q: Where should Klucel Hydroxypropylcellulose be stored for optimal stability?
A: Store Klucel in a cool, dry place with the container tightly closed. This maintains its quality, prevents moisture absorption, and ensures its shelf life of up to 24 months as per supplier guidelines.
Q: What are the benefits of using Klucel in pharmaceutical applications?
A: Klucel offers excellent binding properties, enhances tablet strength, provides effective film formation, and is compatible with most pharmaceutical actives. Its high purity and odorless profile further ensure product safety and patient acceptability.
Q: Is Klucel Hydroxypropylcellulose sensitive to pH changes during formulation?
A: Klucel is stable in neutral to mildly acidic conditions (pH 5.0-8.5 in 1% solution). Extreme pH environments should be avoided to maintain its functional integrity and performance.