Periodic acid is an inorganic acid commonly used as an oxidizing agent. Periodic acid oxidation is one of the steps in the periodate-resorcinol assay, used in the determination of sialic acid.Periodic acid reacts with 1,2 glycol linkage of carbohydrates to form aldehydes which can be stained by Schiffs reagent. Therefore periodic-acid-Schiffs reagent (PAS) is used in histochemistry to determine carbohydrates in tissue sections.
Periodic acid may be used in the following reactions:
Oxidation of alcohols to ketones and aldehydes.
Oxidation hydroxylamine derivatives.
Oxidation of arenes to quinones
Deprotection of the dithio- and oxathio-derivatives.
Oxidative degradation of epoxidized natural rubber (ENR).
Oxidation of urazoles and bis-urazoles to triazolinediones.
Oxidative cleavage of glucosazone
| grade | ACS reagent |
| | |
| assay | 99% |
| 99.0-101.0% (ACS specification) | |
| impurities | 0.01% insolubles |
| 0.01% other halogens | |
| ign. residue | 0.01% |
| mp | 122 C (lit.) |
| anion traces | sulfate (SO42-): 0.01% |
| cation traces | Fe: 0.003% |
| heavy metals: 0.005% |
CAS Number 10450-60-9
Empirical Formula (Hill Notation) H5IO6
Molecular Weight 227.94

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