Periodic acid is an inorganic acid commonly used as an oxidizing agent. Periodic acid oxidation is one of the steps in the periodate-resorcinol assay, used in the determination of sialic acid.Periodic acid reacts with 1,2 glycol linkage of carbohydrates to form aldehydes which can be stained by Schiffâ€™s reagent. Therefore periodic-acid-Schiffâ€²s reagent (PAS) is used in histochemistry to determine carbohydrates in tissue sections.
Periodic acid may be used in the following reactions:
â€¢ Oxidation of alcohols to ketones and aldehydes.
â€¢ Oxidation hydroxylamine derivatives.
â€¢ Oxidation of arenes to quinones
â€¢ Deprotection of the dithio- and oxathio-derivatives.
â€¢ Oxidative degradation of epoxidized natural rubber (ENR).
â€¢ Oxidation of urazoles and bis-urazoles to triazolinediones.
â€¢ Oxidative cleavage of glucosazone
|99.0-101.0% (ACS specification)|
|â‰¤0.01% other halogens|
|mp||122 Â°C (lit.)|
|anion traces||sulfate (SO42-): â‰¤0.01%|
|cation traces||Fe: â‰¤0.003%|
|heavy metals: â‰¤0.005%|