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(±)-α-Lipoic acid

(±)-α-Lipoic acid
(±)-α-Lipoic acid
Product Code : 512
Product Description

(±)-α-Lipoic acid

  • Synonym: (±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-α-Lipoic acid, DL-6,8-Thioctic acid, Lip(S2)

    • Empirical Formula (Hill Notation): C8H14O2S2

    • Molecular Weight: 206.33

    • CAS Number: 1077-28-7

 biological source  


synthetic
description   Oxidized form
assay   ≥99% (titration)
form   powder
solubility   ethanol: soluble50 mg/mL
Gene Information   human ... ACHE(43), BCHE(590)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)

Description

Packaging

1, 5, 25, 50 g in poly bottle

500 mg in poly bottle

Preparation Note

(±)-α-Lipoic acid (α-LA) is soluble in ethanol at 50 mg/ml

Application

α-LA can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats4. It has also been used to analyze ROS production in astrocytes5.

Biochem/physiol Actions

Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. 


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