Plasdone S-630 and S-630 Ultra copovidone

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Plasdone S-630 and S-630 Ultra copovidone Specification

Density
1.22 Gram per cubic centimeter(g/cm3)

Usage
Pharmaceutical excipient for tablet and capsule formulations

Boiling point
Not applicable (decomposes before boiling)

Molecular Weight
90,000700,000 (average)

Physical State
Solid

Packaging Type
Fiber drum or HDPE bags

Ph Level
3.07.0 (1% aqueous solution)

Shelf Life
24 months from date of manufacture

CAS No
25086-89-9

Molecular Formula
(C6H9NO)n(C4H6O2)m

Purity
>99%

Storage Instructions
Store in a cool, dry place; keep container tightly closed

Size
Custom packaging sizes

Melting Point
150170 C

Grade
Pharmaceutical Grade

Type
Copovidone

Application
Binder and film former in pharmaceutical tablet formulations

Appearance
White to off-white, free-flowing powder

Purity(%)
>99%

Plasdone S-630 and S-630 Ultra copovidone Trade Information

Payment Terms
Cash in Advance (CID), Cash Advance (CA)

Supply Ability
3 Per Week

Main Export Market(s)
Western Europe, Australia, North America, Eastern Europe, Middle East, Central America, South America, Asia, Africa

About Plasdone S-630 and S-630 Ultra copovidone

Chemistry: PVP polymers and VP derivatives

Plasdone S-630 copovidone is a 60:40 random,linear copolymer produced by the free radical polymerization ofN-vinyl-2-pyrollidone and vinyl acetate. The pyrrolidone ring is responsiblefor excellent water solubility, adhesion, film forming and solubilizationproperties, while the vinyl acetate monomer reduces glass transitiontemperature (Tg) and hygroscopicity compared to homopolymers of pyrrolidone(PVP). Well-known in the industry as a multipurpose excipient, copovidonefunctions as a binder, solubilizer/solid dispersion carrier and film former ina variety of pharmaceutical formulations.

features and benefits:

Plasdone S-630 Ultra copovidone isa grade of Plasdone S-630 designed to provide better performance in tabletformulations, hot melt extrusion (HME) and continuous processing by offeringsuperior benefits compared to the original Plasdone S-630 copovidone.

features and benefits (in addition to theabove):

efficient,high throughput, energy saving binder/solubilizer/carrier for hot meltextrusion and continuous processes with enhanced processability and stability

Exceptional Tablet Binding Performance

Plasdone S-630 and S-630 Ultra are recognized for their outstanding binding and film-forming capabilities, making them ideal for improving the cohesion and mechanical strength of tablets. The copovidone enhances solid dosage form quality, ensuring uniformity and robustness while facilitating the incorporation of challenging active ingredients.

Enhanced Drug Dissolution for Poorly Soluble Compounds

These copovidone grades help pharmaceutical formulators achieve better dissolution rates for drugs with poor solubility. By improving wettability and dispersion within the formulation, Plasdone S-630 and Ultra enable faster and more efficient drug release, benefiting both bioavailability and therapeutic effectiveness.

Safety, Compliance, and Versatile Compatibility

Plasdone S-630 products comply with global pharmaceutical standards including USP/NF for microbial limits and residual solvents. With heavy metals below 10 ppm, low moisture, and pH neutrality, these excipients blend seamlessly with most actives and excipients, offering safety, flexibility, and suitability for a range of pharmaceutical applications.

FAQ's of Plasdone S-630 and S-630 Ultra copovidone:

Q: How is Plasdone S-630 or S-630 Ultra typically used in pharmaceutical formulations?

A: Plasdone S-630 and S-630 Ultra are primarily used as binders and film-formers in the manufacture of tablets and capsules. They are added during granulation or direct compression processes to enhance mechanical strength and improve the dissolution profile of the final dosage form.

Q: What are the main benefits of using Plasdone S-630 copovidone in tablet production?

A: This copovidone offers excellent binding properties, resulting in stronger and more uniform tablets. It also enhances the dissolution of poorly soluble drugs, improving their bioavailability, and acts as a superior film former for tablet coatings.

Q: When should Plasdone S-630 Ultra be preferred over other binders?

A: Plasdone S-630 Ultra is ideal when a formulation requires not only strong tablet binding and film formation but also improved solubility and dissolution of active pharmaceutical ingredients, making it suitable for challenging formulations with poor water solubility.

Q: Where can pharmaceutical manufacturers source Plasdone S-630 products in India?

A: Pharmaceutical manufacturers and traders can obtain Plasdone S-630 and S-630 Ultra from authorized suppliers and distributors throughout India. Custom packaging options, such as fiber drums or HDPE bags, are typically available to suit different production needs.

Q: What process steps are recommended for incorporating Plasdone S-630 into a formulation?

A: Plasdone S-630 can be incorporated through wet granulation or direct compression processes. It should be blended with actives and other excipients, then compacted or granulated as required to achieve cohesive and robust tablets or capsules.

Q: How should Plasdone S-630 be stored to maintain its quality?

A: It should be stored in a cool, dry environment with the container tightly closed to prevent moisture uptake and contamination. Following these instructions ensures the excipient retains its physical and chemical integrity throughout its 24-month shelf life.

Q: What are the compliance and safety specifications of Plasdone S-630 and Ultra?

A: Both grades comply with pharmacopeial standards for residual solvents and microbial limits, are low in heavy metals (<10 ppm), and are compatible with most pharmaceutical actives and excipients, ensuring safety and reliability in finished pharmaceutical products.

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