()-PPHT hydrochloride

()-PPHT hydrochloride

100 Onwards INR

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Product Details:

Molecular Formula C5H6ClN5
Usage Clinical,Hospital
Physical Form Powder
Chemical Name PPHT hydrochloride
Purity(%) 98%
Supply Ability : 5000 Kilograms Kg Per Month
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Price And Quantity

Minimum Order Quantity 1 Kilograms
Price 100 Onwards INR

Product Specifications

Molecular Formula C5H6ClN5
Purity(%) 98%
Physical Form Powder
Chemical Name PPHT hydrochloride
Usage Clinical,Hospital

Trade Information

Payment Terms Cash in Advance (CID), Cash Advance (CA)
Supply Ability 5000 Kilograms Kg Per Month
Delivery Time 2-8 Week
Sample Available Yes
Sample Policy Sample costs shipping and taxes has to be paid by the buyer
Main Export Market(s) Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
Main Domestic Market All India

Product Description

()-PPHT hydrochloride

Synonym: ()-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434
- Empirical Formula (Hill Notation): C₂₁H₂₇NO HCl
- Molecular Weight: 345.91
- CAS Number: 71787-90-1

assay

	98% (HPLC)
form	solid
color	off-white
solubility	DMSO: 10 mg/mL
	H₂O: 2 mg/mL
Gene Information	human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Biochem/physiol Actions

Potent D₂ dopamine receptor agonist.

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of ()-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 (()-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Features and Benefits

This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC¹²⁸⁰), a biologically annotated collection of high-quality, ready-to-screen compounds.

NATIONAL ANALYTICAL CORPORATION - CHEMICAL DIVISION

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