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(±)-PPHT hydrochloride

(±)-PPHT hydrochloride
(±)-PPHT hydrochloride
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Product Code : 528
Price And Quantity
  • Minimum Order Quantity
  • 1 Kilograms
  • Price
  • 100 Onwards INR
Product Specifications
  • Physical Form
  • Powder
  • Molecular Formula
  • C5H6ClN5
  • Usage
  • Clinical,Hospital
  • Chemical Name
  • PPHT hydrochloride, Other
  • Purity(%)
  • 98%
Product Description

(±)-PPHT hydrochloride

  • Synonym: (±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434

    • Empirical Formula (Hill Notation): C21H27NO · HCl

    • Molecular Weight: 345.91

    • CAS Number: 71787-90-1

 

assay  


≥98% (HPLC)
form   solid
color   off-white
solubility   DMSO: ≥10 mg/mL
  H2O: ≥2 mg/mL
Gene Information   human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Biochem/physiol Actions

Potent D2 dopamine receptor agonist.

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Features and Benefits

This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds.

 

 

Trade Information
  • Payment Terms
  • Cash in Advance (CID), Cash Advance (CA)
  • Supply Ability
  • 5000 Kilograms Kg Per Month
  • Delivery Time
  • 2-8 Week
  • Sample Available
  • Yes
  • Sample Policy
  • Sample costs shipping and taxes has to be paid by the buyer
  • Main Export Market(s)
  • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
  • Main Domestic Market
  • All India

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