(±)-PPHT hydrochloride

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Product Code : 528

Product Description

(±)-PPHT hydrochloride

Synonym: (±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434
- Empirical Formula (Hill Notation): C₂₁H₂₇NO · HCl
- Molecular Weight: 345.91
- CAS Number: 71787-90-1

assay

	â‰¥98% (HPLC)
form	solid
color	off-white
solubility	DMSO: â‰¥10 mg/mL
	H₂O: â‰¥2 mg/mL
Gene Information	human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Description

Biochem/physiol Actions

Potent D₂ dopamine receptor agonist.

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Features and Benefits

This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC^®¹²⁸⁰), a biologically annotated collection of high-quality, ready-to-screen compounds.