()-PPHT hydrochloride

About ()-PPHT hydrochloride

(+/-)-PPHT hydrochloride Synonym: (+/-)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434 Empirical Formula (Hill Notation): C21H27NO HClMolecular Weight: 345.91CAS Number: 71787-90-1 assay 98% (HPLC) form solid color off-white solubility DMSO: 10mg/mL H2O: 2mg/mL Gene Information human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816) Description Biochem/physiol Actions Potent D2 dopamine receptor agonist. A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (+/-)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((+/-)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity. Features and Benefits This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC), a biologically annotated collection of high-quality, ready-to-screen compounds.