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()-PPHT hydrochloride

()-PPHT hydrochloride

100 Onwards INR

Product Details:

  • Usage Clinical,Hospital
  • Physical Form Powder
  • Molecular Formula C5H6ClN5
  • Chemical Name PPHT hydrochloride
  • Purity(%) 98%
  • Supply Ability : 5000 Kilograms Kg Per Month
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Price And Quantity

  • 1 Kilograms
  • 100 Onwards INR

Product Specifications

  • C5H6ClN5
  • Powder
  • PPHT hydrochloride
  • Clinical,Hospital
  • 98%

Trade Information

  • Cash Advance (CA), Cash in Advance (CID)
  • 5000 Kilograms Kg Per Month
  • 2-8 Week
  • Yes
  • Sample costs shipping and taxes has to be paid by the buyer
  • Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
  • All India

Product Description

()-PPHT hydrochloride

  • Synonym: ()-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434

    • Empirical Formula (Hill Notation): C21H27NO HCl

    • Molecular Weight: 345.91

    • CAS Number: 71787-90-1



98% (HPLC)
form   solid
color   off-white
solubility   DMSO: 10 mg/mL
  H2O: 2 mg/mL
Gene Information   human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)


Biochem/physiol Actions

Potent D2 dopamine receptor agonist.

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of ()-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 (()-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.

Features and Benefits

This compound is also offered as part of Sigmas Library of Pharmacologically Active Compounds (LOPAC1280), a biologically annotated collection of high-quality, ready-to-screen compounds.



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