AquaSolve Hypromellose Acetate Succinate (HPMCAS)

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AquaSolve Hypromellose Acetate Succinate (HPMCAS)

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MOQ : 1 Piece

AquaSolve Hypromellose Acetate Succinate (HPMCAS) Specification

Melting Point
Approximately 150C

Usage
Pharmaceutical formulations for modified release

Storage Instructions
Store in a cool, dry place in tightly closed container

Size
Custom particle size available

Packaging Type
Fiber drum, HDPE drum, customized packaging

Purity
High purity

Shelf Life
2 years when properly stored

Molecular Weight
Approx. 180,000

CAS No
126126-17-2

Ph Level
6.0 - 8.0 (1% solution)

Physical State
Solid

Molecular Formula
Variable (based on substitution level)

Density
1.3 Gram per cubic centimeter(g/cm3)

Grade
Pharmaceutical Grade

Type
Polymer / Excipient

Application
Used as a film forming agent, enteric coating and sustained release matrix for solid dosage pharmaceuticals

Appearance
White to off-white powder

Purity(%)
99%

AquaSolve Hypromellose Acetate Succinate (HPMCAS) Trade Information

Minimum Order Quantity
1 Piece

Payment Terms
Cash in Advance (CID), Cash Advance (CA)

Supply Ability
3 Pieces Per Month

Main Export Market(s)
Australia, North America, South America, Eastern Europe, Western Europe, Middle East, Africa, Central America, Asia

Main Domestic Market
All India

Certifications
ISO CERTIFICATE: 9001:2015

About AquaSolve Hypromellose Acetate Succinate (HPMCAS)

AquaSolve Hypromellose Acetate Succinate (HPMCAS)

AquaSolve HPMCAS is a mixture of acetic acid andmonosuccinic acid esters of hydroxypropylmethylcellulose. AquaSolve HPMCAS isused as a solid dispersion polymer for bioavailability enhancement of poorlysoluble active pharmaceutical ingredients(APIs). The versatility of thispolymer in addressing solubility issues is a result of its unique properties.These properties lead to enhanced absorption when HPMCAS-based soliddispersions are dosed orally.

Features and benefits of AquaSolve HPMCAS

Feature

Several substitution ranges

Low solution viscosity in multiple organic solvents

High Tg

Performance matches monographcompliant competitiveproducts

HPMCAS is amphiphilic

Enteric polymer, so partially ionized above pH 5

Benefit

Scope for API-dependent formulation flexibility

Economical and controllable spray-dried dispersionprocesses

Excellent physical stability due to low drug mobility

Reduced risk in excipient sourcing and ease ofinterchangeability

Insoluble drug molecules interact with the hydrophobicregions; hydrophilic regions allow the formation of colloids in aqueous solution

Charge on the polymer minimizes the formation of largeagglomerates, thus stabilizing drug-polymer colloids

AquaSolve HPMCAS is also used as an enteric coatingpolymer and in preparation of sustained drug-release formulations; the releaserate of the API from the matrix is pH dependent.

AquaSolve HPMCAS is available in three gradesdifferentiated by degree/ratio of substitution. Each grade is available in twoparticle sizes. Consult the product data sheet or the excipient informationpackage for further details on specifications. Additional substitution levelsand ranges are available upon request. Detailed product information isavailable in the AquaSolvea Hydroxypropylmethylcellulose Acetate SuccinatePhysical and Chemical Properties Handbook.

Advanced Excipient for Modified Release Pharmaceuticals

AquaSolve Hypromellose Acetate Succinate (HPMCAS) serves as a premium polymer for pharmaceutical formulations. With high purity and controlled particle size, it ensures consistent performance in modified release, enteric coatings, and film-forming applications. Its stability, low humidity sensitivity, and pharmaceutical compliance make it an ideal choice for safeguarding active ingredients and optimizing therapeutic outcomes.

Superior Solubility and Functional Performance

This excipient is specifically engineered to be soluble in aqueous environments above pH 5.5, enabling effective enteric protection and targeted drug release. AquaSolve HPMCAS maintains a stable viscosity profile and remains solid under a broad range of storage and processing conditions. It is odorless, features high purity (99%), and meets strict pharmacopeial standards for heavy metals and microbiological safety.

Optimized for Safe, Reliable Pharmaceutical Use

AquaSolve HPMCAS meets all key USP/NF requirements and is tested for microbial and heavy metal limits to ensure safety and quality. Supplied in secure packaging options, it remains effective throughout its designated shelf life of two years when stored in a cool, dry place. The product supports custom particle size distributions to suit diverse formulation needs.

FAQ's of AquaSolve Hypromellose Acetate Succinate (HPMCAS):

Q: How should AquaSolve HPMCAS be stored to maintain its stability?

A: AquaSolve HPMCAS should be stored in a cool, dry place in a tightly closed container. Proper storage helps maintain its two-year shelf life and ensures stable performance in pharmaceutical formulations.

Q: What is the recommended process for using AquaSolve HPMCAS as an enteric coating agent?

A: For enteric coatings, dissolve AquaSolve HPMCAS in an appropriate aqueous medium (pH above 5.5). Apply the solution to solid dosage forms using standard pharmaceutical coating equipment. Adjust parameters as needed to match desired film thickness and release profiles.

Q: When is AquaSolve HPMCAS most beneficial in pharmaceutical formulations?

A: AquaSolve HPMCAS is most beneficial when controlled, modified, or sustained drug release is required, or where enteric protection from gastric acid is needed. Its solubility profile and stability support targeted delivery of active ingredients.

Q: What are the main advantages of using AquaSolve HPMCAS in formulations?

A: The main advantages include excellent film-forming properties, low humidity sensitivity, high purity, and compliance with USP/NF standards. It also offers stable viscosity, low odor, and ensures effective protection and release of active pharmaceutical ingredients.

Q: Where can customized packaging or particle size options be requested for AquaSolve HPMCAS?

A: Customized packaging (fiber drum, HDPE drum) and specific particle size distributions can be arranged through your supplier or trader upon ordering, catering to unique formulation or production requirements.

Q: How does AquaSolve HPMCAS compare in terms of safety and compliance?

A: AquaSolve HPMCAS meets all USP/NF requirements, with heavy metals 10 ppm, loss on drying 5%, and full compliance with pharmacopeial microbial limits, ensuring safety and suitability for pharmaceutical use.

Q: What is the typical application of AquaSolve HPMCAS in the pharmaceutical industry?

A: It is primarily used as a film forming agent, enteric coating, and sustained release matrix in solid dosage forms, enhancing drug stability, and enabling customized release and absorption profiles.

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