Cavitron and CAVASOL* hydroxypropyl-- and hydroxypropyl--cyclodextrins (HPBCD and HPGCD)

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Cavitron and CAVASOL* hydroxypropyl-- and hydroxypropyl--cyclodextrins (HPBCD and HPGCD) Specification

Molecular Formula
(C42H70-nO35(C3H6O)n) (HPBCD); (C48H80-nO40(C3H6O)n) (HPGCD)

Molecular Weight
1380 (HPBCD), 1550 (HPGCD)

Packaging Type
HDPE drums, PE bags, Customized packaging

Shelf Life
24 months

Ph Level
5.0 - 8.0 (1% aqueous solution)

Density
0.60 Gram per cubic centimeter(g/cm3)

Storage Instructions
Store in a cool, dry, and well-ventilated place, tightly closed

Physical State
Solid

Purity
>98%

CAS No
128446-35-5 (HPBCD), 128446-36-6 (HPGCD)

Size
Customized as per requirement

Melting Point
Decomposes above 280C

Usage
Solubilizing agent, excipient, stabilizer

Grade
Pharmaceutical Grade

Type
Hydroxypropyl--cyclodextrin (HPBCD) and Hydroxypropyl--cyclodextrin (HPGCD)

Application
Pharmaceutical, food, cosmetics, analytical reagent

Appearance
White to off-white, amorphous powder

Purity(%)
>98%

Cavitron and CAVASOL* hydroxypropyl-- and hydroxypropyl--cyclodextrins (HPBCD and HPGCD) Trade Information

Payment Terms
Telegraphic Transfer (T/T), Cash in Advance (CID), Cash Advance (CA)

Main Export Market(s)
Western Europe, Australia, North America, South America, Eastern Europe, Middle East, Central America, Asia, Africa

About Cavitron and CAVASOL* hydroxypropyl-- and hydroxypropyl--cyclodextrins (HPBCD and HPGCD)

CavitronAAA and CAVASOL* hydroxypropyl-AA- and hydroxypropyl-AA3-cyclodextrins (HPBCD and HPGCD)

Chemistry: Cyclodextrins

The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-AA- or hydroxypropyl-AA3-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the Cavitron and CAVASOL HPBCDs and HPGCDs capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation, and also can increase solubility of poorly soluble compounds in oral drug delivery systems. Purification of the Cavitron cyclodextrins to remove endotoxins allows their use for solubilization of drugs for parenteral drug products.

Exceptional Solubility and Purity

Cavitron and CAVASOL* HPBCD and HPGCD dissolve readily in water, making them highly effective for improving the solubility of poorly soluble compounds. They are manufactured to surpass 98% purity, ensuring both efficacy and safety in sensitive pharmaceutical, food, and cosmetic applications. Their odorless and stable profile complements diverse formulation needs while maintaining product quality.

Regulatory Compliance and Safety

These cyclodextrins comply with Ph. Eur., USP, and ICH standards, ensuring low levels of impurities such as heavy metals and endotoxins. With bacterial endotoxins below 0.25 EU/mg and heavy metals under 10 ppm, these materials are exceptionally safe for end-product use. Pharmaceutical-grade quality and proper identification protocols further reinforce reliability.

Versatile Applications Across Industries

HPBCD and HPGCD serve as solubilizing agents, excipients, stabilizers, and analytical reagents, benefiting pharmaceutical, food, and cosmetic industries alike. Their high stability, customizable packaging, and adaptable particle size enable convenient integration into different formulations, tools, and production environments.

FAQ's of Cavitron and CAVASOL* hydroxypropyl-A- and hydroxypropyl-AA3-cyclodextrins (HPBCD and HPGCD):

**Q: How do Cavitron and CAVASOL* cyclodextrins improve solubility in formulations?**

A: Cavitron and CAVASOL* HPBCD and HPGCD significantly enhance the solubility of poorly water-soluble substances by forming inclusion complexes. These complexes can increase the bioavailability, stability, and dispersibility of active ingredients in pharmaceutical, food, and cosmetic formulations.

**Q: What grade and purity are Cavitron and CAVASOL* HPBCD and HPGCD?**

A: Both products are pharmaceutical grade with a purity exceeding 98%. This ensures suitability for sensitive formulations in pharmaceuticals, foods, and cosmetics, meeting stringent international standards (Ph. Eur., USP, and ICH guidelines).

Q: When should these cyclodextrins be used in a formulation process?

A: They should be incorporated during the formulation stage whenever there is a need to improve solubility, stability, or taste-masking properties of active compounds. Their use is particularly important for hydrophobic substances to increase efficacy and shelf-life.

Q: Where are these cyclodextrins typically applied?

A: HPBCD and HPGCD are widely applied in pharmaceuticals (as solubilizers and stabilizers), the food industry (as carriers or flavor protectors), cosmetics (to stabilize and solubilize active ingredients), and for analytical purposes as reagents.

Q: What are the benefits of using HPBCD and HPGCD over regular cyclodextrins?

A: Hydroxypropyl substitution enhances water solubility and safety profile compared to native cyclodextrins, providing better encapsulation efficiency, lower toxicity, and broader compatibility across diverse formulation matrices.

**Q: How should Cavitron and CAVASOL* cyclodextrins be stored and handled?**

A: They should be stored in a tightly closed container within a cool, dry, and well-ventilated area to maintain their stability and prolong shelf life (up to 24 months). Packaging options include HDPE drums and PE bags, with customization available based on requirements.

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